Protein Details: Chloride channel protein ClC-Kb

Protein ID

ICDB_Pro_1684

Protein Name

Chloride channel protein ClC-Kb

Gene Name

clcnkb

Organism

Xenopus laevis (African clawed frog)

Length

689 amino acids

AlphaFoldDB

AF-Q9W701-F1-model_v4.pdb

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; the stabilization of membrane potential; signal transduction and transepithelial transport.

Sequence

MSRVLVIEQREGEEKTLIQKHIFRPFPNTRRVVIDHLQRLKNFLFRIGDDWYFLFALGVIMALISFTMDFTVSKMLNAHRWLQQELGGNVLLRYLSWIVYPIALVAFSTGFAQSITPHSGGSGIPELKTILSGVILEEYLTIKNFGAKVVGLTCTLSAGSTMFLGKVGPFVHLSSMIAAYLGRMRTSVAGDYENKSKEHEMLVAAAAVGVSTVFGAPISGVLFSVEVMSSHFAIRNYWRGFFAATCGAFVFRLLAVFNSEQETITAVFKTSFKISFPFDLPEMFFFAILGVVCGLIGCAYLFCQRWLLGYVRRNSLTSKLLASDKPMYSALVALLISSITFPESLGQFLASRLTMKELLTSLFDNRTWWISLSQNSSLDRSPLVDPNNLWLEWANPQFTIFGTLAFFIIMKFWMFILATTLPMPAGYFMPVFVFGAAIGRLVGETVALLYPEGIAADGIVNPIIPGGYAWQGAPAYSGAVTHSVSTALLAFEATGQIAHILPVILCVLIANAFTQKLQPSFYDGTIIVKKLPYLPRIRSRDIDSYKVNTEEFMNPDIRVLPREAGFEDVLKVITASDDSEYPVVDNTESQVLVGTVKRPQLIHFLETHESHERAGPTEKENLSEGNLGEACSIEPVTFQLSTWTSLHQAHHLFELLHLQKAFVTKYGRIVGQVTRKEMKKAIEDLANPK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 122; /ligand="chloride" ; BINDING 260; /ligand="Ca(2+)"; BINDING 262; /ligand="Ca(2+)"; BINDING 279; /ligand="Ca(2+)"; BINDING 282; /ligand="Ca(2+)"; BINDING 428; /ligand="chloride"

Disease

Location

Expressed in two distinct regions of the kidney; the proximal convoluted tubule and the diluting segment

DOI ID

10.1042/bj3400737

RefSeq

NP_001079308.1